منابع مشابه
Ox liver glutamate dehydrogenase
1. The effect of pyridoxal 5'-phosphate on the activity of ox liver glutamate dehydrogenase towards different amino acid substrates was investigated. 2. Both alanine and glutamate activities decreased steadily in the presence of pyridoxal 5'phosphate. 3. The alanine/glutamate activity ratio increased as a function of inactivation by pyridoxal 5'-phosphate, indicating that glutamate activity is ...
متن کاملRegulation of Bovine Glutamate Dehydrogenase
The activity of bovine liver glutamate dehydrogenase is affected in several ways depending on substrate concentrations and pH. At pH 6.5 and below, both oxidative deamination and reductive amination reactions are inhibited by ADP. At pH 7.0 and above both activatory and inhibitory effects can be observed depending on substrate concentrations. The effects are explicable in terms of a model with ...
متن کاملNeumspura Glutamate Dehydrogenase and its Mutant Forms
Ralph, P. & Rich, A. (1971) Biochemistry 10, 4717-4725 Rossignol, B., Herman, G. & Clauser, H. (1969) Biochem. Biophys. Res. Commun. 34,111-119 Stavnezer, J. & Huang, R. C. C. (1971) Nature (London) New Biol. 237, 172-176 Stevens, R. H. & Williamson, A. R. (1972) Nature (London) New Biol. 239, 143-146 Svasti, J. & Milstein, C. (1972) Biochem. J. 128, 4 2 7 4 Swan, D., Aviv, H. & Leder, P. (1972...
متن کاملGlutamate dehydrogenase biosynthesis in amphibian liver preparations.
Glutamate dehydrogenase (EC 1.4.1.3) (GDH) was studied with a system in vifro of tadpole and frog liver cube suspensions. A rise in GDH activity was observed in liver from tadpoles immersed in thyroxine (2.6 X lo-* M) for 8 days. A small rise in enzyme activity was observed in vitro in liver cubes from premetamorphic tadpoles. In the presence of thyroxine (2.6 X lo-* M to 2.6 X lo-lo M) or trii...
متن کاملDual nucleotide specificity of bovine glutamate dehydrogenase
The thionicotinamide analogues of NAD+ and NADP+ were shown to be good alternative coenzymes for bovine glutamate dehydrogenase, with similar affinity and approx. 40% of the maximum velocity obtained with the natural coenzymes. Both thionicotinamide analogues show non-linear Lineweaver-Burk plots, which with the natural coenzymes have been attributed to negative co-operativity. Since the reduce...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)83975-3